Bose ElectroForce BioDynamic Test Instruments0 pages

Bose® ElectroForce® BioDynamic®
ttttttTest Instruments
Characterization and Stimulation
tt
in a Physiological Environment
Bose® ElectroForce® BioDynamic® test instruments provide characterization,
stimulation, and tissue growth solutions for biomaterials and biological specimens
within a sterile cell culture media environment. The instruments can be used
for the evaluation of a variety of specimens, including biomaterials, acellular and
cell-seeded scaffolds, native tissue samples and tissue-engineered constructs.
BioDynamic test instruments can simulate in vivo conditions and bridge the gap
between basic in vitro exploratory studies in culture dishes and in vivo animal
experiments. BioDynamic test instruments provide specimen loading and media
circulation control under customizable, programmable conditions. Each test
chamber is packaged with its own closed media flow loop system to minimize
contamination.

Compact Design Fits in an Incubator
The system is available in a single-axis (tension/compression) or dual-axis (tension/
compression and pulsatile flow) configuration, with torsional options also available.
The test chamber can be easily removed from the motor assembly to accommodate
experimental setup, or to conduct experiments with multiple test chambers on a
revolving basis.
The BioDynamic instrument is provided as a complete system with a media perfusion
flow loop, load cell, displacement transducers, pressure transducers (if applicable),
and a chamber stand for use in a sterile flow hood. It is available as a 200 N
maximum force system, and can be packaged for a variety of tissue applications.

ElectroForce® BioDynamic® test
instrument for dynamic compression,
tension, and perfusion flow

Multiple Applications
Orthopaedic Research
Dynamic tissue and biomaterial characterization and stimulation can be done under
tension/compression and perfusion flow loading regimes. Tensile grips and porous and
non-porous platens used for compression can be used within the same chamber. Tissues
that have been tested include bone, cartilage, meniscus, spinal disc, ligament and tendon,
as well as engineered biomaterials. A fully integrated digital video extensometer can be
added to the system for primary, secondary and shear strain measurements.

Vascular Applications
Accurate pulsatile loading (with programmable stroke volume and frequency) and tension/
compression to tubular specimens such as native arteries and veins, vascular grafts, and
tissue-engineered blood vessels can be done. Pulsatile waveforms can be created, and creep
and elasticity can be studied by using the laser micrometer to measure diametric changes
in samples due to pulsatile flow and pressure. Chemical sensors to measure pH and oxygen
are also available.
BioDynamic chamber for mechanical
stimulation and characterization
of samples in a physiologicallyrelevant environment