5900 BioDynamic Test Instruments0 pages

ElectroForce® 5900
ttBioDynamic® Test Instrument
Advanced Performance to
ttSimulate In Vivo Conditions
Bose Corporation has developed a multi-specimen BioDynamic® test instrument, in
collaboration with Dr. David Williams’ group at Loughborough University, for intervertebral
disc and other orthopaedic applications to mimic the complex loading that tissues experience
in vivo. Spinal discs, cartilage and bone tissues, scaffolds and tissue-engineered constructs
can be characterized under multiaxial stimulation. The 5900 BioDynamic test instrument
accommodates four disc specimens in a single chamber mounted between porous
compression platens. The specimens are subjected to axial compression, pulsatile flow
through porous platens, and radial cyclic hydrostatic pressure while maintaining sterility
in a cell culture incubator. All system components in contact with the samples and the
fluid are sterilizable to allow long term stimulation and characterization in an incubator.
Bose® BioDynamic test instruments are integrated systems that combine ElectroForce®
linear motors with environmental technologies and fully-automated computer controls
and software. The simple and durable proprietary moving-magnet motor design provides
excellent dynamic performance and operates without friction, which is an important
feature for high resolution, low force testing. ElectroForce test instruments are controlled
by the WinTest® digital control system which provides data acquisition, waveform
generation and instrument control. Up to 8 actuators can be operated from the same
personal computer and up to 32 input channels are available for measurements. This
control and software capability allows multiaxial loading to mimic physiologic conditions
and data acquisition from multiple sensors.
ElectroForce® 5900 BioDynamic®
Test Instrument

System Description
Axial compression

Pressure control

Mean flow pumps
ElectroForce® 5900 BioDynamic® Test Instrument
and Main Subsystem Components

Pulsatile
flow

The chamber accommodates 4 samples with a
clear membrane sheath surrounding each sample
circumferentially. The chamber’s cyclic hydrostatic
pressure is exerted on each sample via the
flexible membrane and is the same for all 4 samples.
Compression loading is applied by an ElectroForce
motor so that displacement is the same for all
samples while the load is divided among the
number of samples. Samples are perfused by steady
or pulsatile flow through porous platens to improve
nutrient delivery to cells. Fluid flow parameters are
programmable to suit different phases of stimulation
and characterization.
Each sample has its own load cell as well as two
pressure transducers, one upstream (flow inlet) and
one downstream (flow outlet) of each sample while
an additional pressure transducer measures
chamber pressure.