Combiflash0 pages

TM

Teledyne Isco’s CombiFlash Rf+ Lumen Flash
Chromatography System with integrated ELSD
improves the detection of compounds with little to
no UV chromophore. When purifying your
compounds, this system gives you greater detection
sensitivity for complex separations.

Internal Integration of
Evaporative Light Scattering
Detection
The ELSD withdraws a miniscule portion of the
liquid eluting from the chromatographic column.
This fluid is then nebulized using a stream of inert
gas that forms an aerosol cloud of solvent droplets
containing your compound. The aerosol cloud is
then evaporated, leaving particles of dried
compound.
The gas stream carries these particles to the detector
where a laser light illuminates the gas stream. When
compound is present, the particles cause the light
beam to scatter, indicating its presence and creating
a detector signal.

The Process

Detection

Evaporation

Nebulization
Carrier Gas

Column
Efuent

Smallest Footprint of any
Flash + ELSD System
Smallest Flash system with
integrated UV, UV-Vis, and ELSD
detection
Minimize bench space footprint
(Reduce system footprint by 30%).
Maximize detection with UV-Vis,
All-wavelength, and ELSD
technology (Equivalent to using
external ELSD detector).
Optimize detection of compounds
with little or no chromophores such
as carbohydrates, steroids, and lipids.