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Vitiligo and Psoriasis
VITILIGO AND PSORIASIS:
TRADITIONAL THERAPY
AND NEW DEVELOPMENTS
There are pharmaceutical, physical and surgical treatments are available, sometimes
be combined:
- Heliotherapy
- Photo-chemotherapy (PUVA-therapy)
- PUVA-therapy with topical minoxidil
- Therapy with cystine and sunrays therapy (oral cystine plus heliotherapy)
- Therapy with folic acid and vitamin B12 (plus ascorbic acid) therapy
- Total skin depigmentation (20% MBEH cream)
- Corticosteroid therapy
- Surgical treatments
- In progress:
*Skin abrasion and topical application of 5-fluorouracil (5-FU)
*Autologous melanocyte transplantation
*Selective and focused micro-phototherapy (Ratok®derm)
Always known and until recently underestimated and considered
untreatable, vitiligo is a progressive chronic dermatosis that
occurs anywhere in the human body, at all ages, and without any
apparent causes, showing itself through patches with poor or no
pigmentation. Such patches are often symmetrically arranged
and well recognizable from the surrounding skin.
Vitiligo has a very irregular and unpredictable onset and course
and is characterized by white patches, which mostly develop
centrifugally. These patches are due to a disruption of the skin,
mucosal, and retinal melanocytes.
Statistically, according to the World Health Organization, vitiligo affects more than 1% of the world population with no
differences as far as geography, race, or gender are concerned. People aged 20 to 40 are most heavily affected.
While this disease has been known for thousands of years, its aetiology is still unknown. Its pathogenesis has not been
fully understood yet, but over the past few years a convincing theory has emerged, which points out to an imbalance
of the melanocytes antioxidant defences (for immune, neurological, self-destructive, or therapy-related causes).
RATOK® DERM DEUS -RK 2000
Phisiopathology of Psoriasis:
Before treatment with Ratok®derm
Psoriasis is an inflammatory, chronic, and relapsing dermatosis
characterized by an unpredictable and bizarre course, with circumscribed erythematous or desquamative, round or oval intersecting patches, whose etiopathogenesis is still somewhat unclear.
The whole skin surface may be affected.
This condition is frequent, affecting about 3% of the world population. Psoriasis is a genetically-determined disease, which equally
affects both men and women and which can develop at any age.
Its frequency largely depends on and changes according to climatic and ethnic factors. Genetic, extra-genetic, and immune factors
are considered responsible for the onset of psoriasis.
More than 36% of cases have a familial course and an early onset. Psoriasis affects 75% of patients and has its peak
at an age of 22 in males and 16 in females.
Sporadic psoriasis (following traumas, infections, drugs, endocrine and metabolic factors, alcohol, cigarette smoke, food,
stress, psychological factors) appears later in life and its action mechanisms are still poorly known.
In both cases, immune factors come into play in the pathogenesis of such condition, however in ways that are not perfectly clear.
10-09-2001
after 26 sessions
After treatment with Ratok®derm
30-11-2001
Before treatment with Ratok®derm
19-12-2001
after 9 sessions
After treatment with Ratok®derm
Psoriasis
There are pharmaceutical, physical and topical treatments treatments are available,
sometimes combined:
- Heliotherapy-Dithranol-Tar
- Photo-chemotherapy (PUVA-therapy)
- UV-B phototherapy
- Combined therapies (UV-A/UV-B/PUVA)
- Drugs interfering with the immune system which are occasionally employed in the
treatment of psoriasis
- In progress:
*Tacrolimus
*Microphoenolic Acid
*Fumaric Acid
*Intravenous infusion of Polyunsaturated Fatty Acids
*Drugless occlusion
*UV-B Laser-therapy
* Selective and focused micro-phototherapy (Ratok®derm)
FINAL GOAL:
Excellent, long-lasting outcomes with the best possible cost-benefit ratio
Quanta System S.p.a. - via IV Novembre, 116 - 21058 Solbiate Olona (VA) - ITALY
www.quantasystem.com – e-mail: quanta@quantasystem.com
This publication and the pictures contained herein may only be fully or partly reproduced in compliance with the Italian Law on copyrights and their use should be authorized by the Editor or the owner
in writing. Any breaches of the Copyright are subject to legal prosecution in compliance with the existing Italian rules on copyrights.
La Nuova Medicina
Reg. Trib. di Parma n. 7/1998
Direttore Responsabile
Federico Cioni
Mattioli 1885
spa - via Coduro 1/b
43036 Fidenza (Parma)
tel 0524/84547
fax 0524/84751
www.mattioli1885.com
DIREZIONE EDITORIALE
Direttore Scientifico
Federico Cioni
Editing Manager
Anna Scotti
Redazione
Valeria Ceci
Natalie Cerioli
MARKETING E PUBBLICITÀ
Direttore Marketing e Sviluppo:
Massimo Enrico Radaelli
Marketing Manager:
Luca Ranzato
Product Manager:
Andrea Villani
Segreteria Marketing:
Martine Brusini
Marketing Coordinator
Manuela Piccinnu
La Nuova Medicina
Mattioli 1885 spa
HEALING ATTEMPTS
- Drug therapy
- Physical therapy
New therapeutic frontiers
20 years of research
Phisiopathology of Vitiligo:
Vitiligo and Psoriasis
22-11-1999
Vitiligo
edited by Federico Cioni
New therapeutic frontiers
20 years of research
It has always been known that many patients affected by psoriasis, vitiligo, and other types of dermatitis get better in the
summertime. UV-radiations, which have always been studied, must be divided into three bands (UV-A 315-380nm/UVB 280-315nm/UV-C 204-280nm; the interval below 200nm is absorbed by the atmosphere) in order to better differentiate their biological effects. Over the years. It has been demonstrated that all the sources of therapeutically effective UVradiations, including sunlight, use the 280-320nm band. This is the starting point of the Selective and Focused MicroPhototherapy, that is the use of a source of light whose concentrated energy’s spectral distribution contains the UV-B
electromagnetic waves required to obtain the best therapeutic effect in the treatment of vitiligo and psoriasis.
Therapies for the treatment of vitiligo and psoriasis are constantly developing.
New therapeutic frontiers
20 years of research
Vitiligo and Psoriasis
Physical therapies: a historical outline of the therapies used since the beginning
of the past century.
VITILIGO AND PSORIASIS:
PHISIOPATHOLOGY
