Considerations When Setting Up a Preclinical In Vivo Imaging Laboratory0 pages

Considerations When Setting Up a Preclinical In Vivo
Imaging Laboratory
Todd A. Sasser1, Ali Bahadur1, Eric Frederick1, W. Matthew Leevy2,3
Author Information: 1- Bruker Preclinical Imaging., 44 Manning Rd, Billerica, MA, 01821; 2- Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University
of Notre Dame, Notre Dame, IN 46556; 3- Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556.

Abbreviations
ALARAt
As Low as Reasonably Achievable
BLIt
Bioluminescence Imaging
CLI t
Cherenkov Luminescence Imaging
CTt
Computed Tomography
DRI t
Direct Radioisotopic Imaging
ECGtElectrocardiogram
EMGt
ElectroMagnetic Interference
HEPA t
High-Efficiency Particle Air
MATSt
Multimodal Animal Transport System
MMABt
Multimodal Animal Bed
MRIt
Magnetic Resonance Imaging
PET t
Positron Emission Tomography
RAIDt
Redundant Array of Inexpensive Disks
RSOt
Radiation Safety Officer
SNRt
Signal-to-Noise Ratio
SPECTt
Single-Photon Emission Computed Tomography
SPFt
Specific Pathogen Free
SUVt
Standard Uptake Value
TtTesla
USRt
Ultra Shield Refrigerated
VtVoltage

Considerations for outfitting a preclinical imaging laboratory
will depend partly on the specific imaging systems in the
laboratory and anticipated workflow of studies that will
be made. Additionally, some aspects of laboratory set-up
are necessary to meet safety and regulatory requirements
while others are intended to facilitate day-to-day laboratory
productivity. This document provides an introduction
to all such considerations, highlighting: general site
requirements, system and software considerations, imaging
accessory requirements, animal care solutions and training/
personnel considerations for setting up single modality
and multimodality preclinical imaging laboratories. Site
requirements and recommendations for specific imaging
systems can be further supported by your system specific
support personnel. Details on system installations, clearance
and weight tolerance requirements will be made available.
For systems that require detailed considerations for room
engineering, including heat sinks and shielding, etc., it is
advisable that facilities and/or contract engineers be consulted
at the earliest stages of the facility design. For systems that
use or produce ionizing radiation, institutional, local, and
national agency guidelines should be considered.