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Zetasizer Helix0 pages
ZETASIZER HELIX
Develop mechanistic insight into protein conformation stability
and aggregation
The Zetasizer Helix delivers structural information at the molecular level, providing
mechanistic insight into the unfolding processes and formation of aggregates in
biopharmaceuticals.
Key benefits
Study samples at formulation
concentration
Understand mechanisms
of aggregation
“Expertise Optional” data
analysis software provides
trend results without making
expert level decisions
Advance data analysis tools
include a full suite of
spectroscopic analysis tools, from
pre-treatment to multivariate
analysis.
The market-leading Zetasizer dynamic light scattering platform is coupled with Raman
spectroscopy for protein size and structural determination. Together, these two
measurements provide unique insights into colloidal and conformation stability of
biopharmaceutical products. The data derived is an effective tool to develop product
understanding, necessary in implementing a Quality by Design strategy. Ultimately, the
ability to probe the mechanisms, not just the results, of product agglomeration can be
used to improve biopharmaceutical formulations.
Data analysis modes, isothermal
incubation, thermal ramp, and
sample series, provide insights
into product stability.
Based on the Zetasizer Nano ZSP, the system retains a suite of protein characterization
capabilities, while adding a new dimension of analysis by coupling with Raman
spectroscopy.
In-depth analysis of secondary
and tertiary protein structure
A Forced Degradation Study: The Reversibility
of Thermal Induced Lysozyme Denaturation
Low volume measurements
(20μl)
30 mg/mL lysozyme in pH 4 citrate phosphate buffer
Monitored size (DLS) and 2° and 3° structural markers (Raman) changes during thermal
ramp experiment
Bidirectional ramp results indicates partial unfolding and conformational changes are
reversible.
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©2015 Malvern Instruments Limited MRK2127-02
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